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Christian Flotho Selected Research

Juvenile Myelomonocytic Leukemia

1/2021Long non-coding RNAs as novel therapeutic targets in juvenile myelomonocytic leukemia.
1/2021International Consensus Definition of DNA Methylation Subgroups in Juvenile Myelomonocytic Leukemia.
1/2021Response to upfront azacitidine in juvenile myelomonocytic leukemia in the AZA-JMML-001 trial.
1/2020CircRNAs Dysregulated in Juvenile Myelomonocytic Leukemia: CircMCTP1 Stands Out.
1/2019Azacitidine is effective for targeting leukemia-initiating cells in juvenile myelomonocytic leukemia.
11/2018The long non-coding RNA landscape in juvenile myelomonocytic leukemia.
1/2018DNA-hypomethylating agents as epigenetic therapy before and after allogeneic hematopoietic stem cell transplantation in myelodysplastic syndromes and juvenile myelomonocytic leukemia.
1/2017Epigenetic dysregulation of the erythropoietic transcription factor KLF1 and the β-like globin locus in juvenile myelomonocytic leukemia.
8/2016MicroRNA fingerprints in juvenile myelomonocytic leukemia (JMML) identified miR-150-5p as a tumor suppressor and potential target for treatment.
1/2016Long-term serial xenotransplantation of juvenile myelomonocytic leukemia recapitulates human disease in Rag2-/-γc-/- mice.
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Christian Flotho Research Topics

Disease

16Juvenile Myelomonocytic Leukemia
01/2021 - 06/2007
7Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
01/2021 - 08/2006
7Leukemia
12/2019 - 07/2005
6Neoplasms (Cancer)
01/2020 - 06/2007
4Residual Neoplasm
01/2021 - 08/2006
3Myelodysplastic Syndromes (Myelodysplastic Syndrome)
10/2020 - 03/2016
2monosomy Chromosome 7
03/2016 - 03/2009
1Carcinoma (Carcinomatosis)
01/2022
1Breast Neoplasms (Breast Cancer)
01/2022
1Hepatic Veno-Occlusive Disease (Disease, Hepatic Veno-Occlusive)
01/2021
1GATA2 Deficiency
10/2020
1Inborn Genetic Diseases (Disease, Hereditary)
10/2020
1Hypertriglyceridemia
09/2020
1Hodgkin Disease (Hodgkin's Disease)
01/2020
1Lymphoma (Lymphomas)
12/2019
1Disease Progression
01/2019
1Acute Promyelocytic Leukemia
08/2017
1Hypersensitivity (Allergy)
08/2016
1Cytopenia
03/2016
1Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
03/2014
1Spinal Stenosis (Stenosis, Spinal)
03/2011
1Kidney Neoplasms (Kidney Cancer)
03/2011
1Gout
03/2011
1Costello Syndrome
09/2010
1Legius syndrome
09/2010
1Cardiofaciocutaneous syndrome
09/2010
1Noonan Syndrome (Female Pseudo-Turner Syndrome)
09/2010
1Neurofibromatosis 1 (Neurofibromatosis Type I)
09/2010
1Myeloproliferative Disorders (Myeloproliferative Disorder)
06/2007
1Genetic Translocation (Chromosomal Translocation)
07/2005
1Chromosome Aberrations (Chromosome Abnormalities)
07/2005

Drug/Important Bio-Agent (IBA)

5Azacitidine (5 Azacytidine)FDA Link
01/2021 - 03/2009
4Biological ProductsIBA
11/2019 - 08/2007
3MicroRNAs (MicroRNA)IBA
01/2022 - 08/2016
3Pharmaceutical PreparationsIBA
09/2020 - 06/2007
3Fetal Hemoglobin (Hemoglobin F)IBA
01/2019 - 03/2016
3DNA (Deoxyribonucleic Acid)IBA
01/2018 - 09/2014
2Cell-Free Nucleic AcidsIBA
01/2022 - 01/2020
2Long Noncoding RNAIBA
11/2018 - 01/2016
1Genetic Markers (Genetic Marker)IBA
01/2021
1blinatumomabIBA
01/2021
1Thioguanine (Tioguanine)FDA Link
01/2021
1RNA (Ribonucleic Acid)IBA
10/2020
1GATA2 Transcription FactorIBA
10/2020
1LipidsIBA
09/2020
1pegaspargase (Oncaspar)FDA Link
09/2020
1GlucocorticoidsIBA
09/2020
1Circular RNAIBA
01/2020
1Circulating Tumor DNAIBA
01/2020
1VorinostatFDA Link
12/2019
1Histone Deacetylase InhibitorsIBA
12/2019
1AcidsIBA
08/2017
1Arsenic Trioxide (Trisenox)FDA Link
08/2017
1RetinoidsIBA
08/2017
1GlobinsIBA
01/2017
1Transcription Factors (Transcription Factor)IBA
01/2017
1Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA
08/2016
1MethyltransferasesIBA
01/2016
1CytokinesIBA
01/2016
1Codon (Codons)IBA
03/2014
1Asparaginase (Elspar)FDA Link
11/2013
1I-kappa B KinaseIBA
10/2011
1Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
09/2010
1Indicators and Reagents (Reagents)IBA
08/2006
1Proteins (Proteins, Gene)FDA Link
07/2005

Therapy/Procedure

11Therapeutics
01/2022 - 07/2005
6Hematopoietic Stem Cell Transplantation
01/2021 - 06/2007
2Drug Therapy (Chemotherapy)
01/2021 - 08/2017
2Transplantation
01/2016 - 01/2015
2Remission Induction
08/2007 - 08/2006
1Consolidation Chemotherapy
01/2021
1Blood Component Removal (Apheresis)
09/2020
1Drug Tapering
03/2016
1Heterologous Transplantation (Xenotransplantation)
01/2016
1Nephrectomy
03/2011